Google DeepMind Solves 50 Year Old Folding Protein Problem

Researchers at Google-owned Artificial Intelligence (AI) company DeepMind have solved a “50-year-old grand challenge” in biology known as the ‘protein folding problem.’

The ‘major scientific advance’ with the latest version of the DeepMind AI system (AlphaFold) reveals what shapes proteins fold into. This achievement has been officially recognised as a solution by the organisers of the biennial protein-structure prediction challenge called Critical Assessment of protein Structure Prediction (CASP).

“This breakthrough demonstrates the impact AI can have on scientific discovery and its potential to dramatically accelerate progress in some of the most fundamental fields that explain and shape our world,” blogged the UK-based firm.

Scientific breakthrough

“Proteins are essential to life, supporting practically all its functions,” explained DeepMind. “They are large complex molecules, made up of chains of amino acids, and what a protein does largely depends on its unique 3D structure.”

“Figuring out what shapes proteins fold into is known as the ‘protein folding problem’, and has stood as a grand challenge in biology for the past 50 years,” the firm stated.

But why is this development so important?

Well, a protein’s shape is closely linked with its function, and the ability to predict this structure unlocks a greater understanding of what it does and how it works.

According to DeepMind, many of the world’s greatest challenges, like developing treatments for diseases or finding enzymes that break down industrial waste, are fundamentally tied to proteins and the role they play.

“We have been stuck on this one problem – how do proteins fold up – for nearly 50 years,” explained Professor John Moult, co-founder and chair of CASP, University of Maryland.

“To see DeepMind produce a solution for this, having worked personally on this problem for so long and after so many stops and starts, wondering if we’d ever get there, is a very special moment,” he added.

Faster drug development

And the breakthrough has prompted reaction from AI experts.

“The Covid-19 pandemic has propelled artificial intelligence (AI) into the limelight,” said Nikolas Kairinos, CEO at “A phenomenon born out of necessity, machines have been pivotal in ensuring sick patients get the medical care that they need, and that the virus can be controlled as much as possible.”

“DeepMind’s latest breakthrough has highlighted the huge potential of AI systems in the medical space going forward,” said Kairinos. “Not only is AI a temporary solution to stem the tide of infections, but it can deliver improvements across all areas of healthcare. The protein structure problem is a challenge researchers have been working on for many years, and which held the promise of opening up new opportunities for drug development.”

“DeepMind’s discovery will advance our understanding of fundamental scientific problems, and enable us to develop better, and faster, treatments for a whole host of medical ailments – from infectious diseases to cancer,” said Kairinos.

“With the right combination of human and artificial intelligence, machines are a powerful force for good,” Kairinos concluded. “The challenge is to build public trust in AI and showcase its enormous potential to improve our lives; DeepMind’s breakthrough will undoubtedly help that cause.”

Tom Jowitt

Tom Jowitt is a leading British tech freelancer and long standing contributor to Silicon UK. He is also a bit of a Lord of the Rings nut...

Recent Posts

AWS re:Invent Conference Welcomes Back Crowds

Over 27,000 attendees and members of the press (including Silicon) attend Amazon Web Services worldwide…

5 hours ago

Head Of Car Giant Stellantis Issues Electric Vehicle Cost Warning

The car manufacturing industry cannot sustain the costs from government demands to shift to electric…

6 hours ago

SpaceX’s Elon Musk Warns Of Bankruptcy Risk Over Engine Issue

SpaceX CEO Elon Musk warns of “disaster” concerning production of Starship Raptor engine that puts…

8 hours ago

Twitter To Remove Photos Tweeted Without Permission

Privacy overstep? Personal photos and videos of private individuals tweeted without the consent of the…

9 hours ago

Facebook Cryptocurrency Executive David Marcus To Leave

Executive in charge of Meta's cryptocurrency efforts, confirms he is leaving after seven years at…

11 hours ago

NY AG Seeks Overseer For Amazon Worker Safety

New York's attorney general asks US judge to appoint someone who will oversee worker safety…

11 hours ago